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Changes in the average abundance of metabolites associated with sexual development in male cats identified as significantly different between EN and CN cats (CN (red) and EN (black)). Scaled intensity is relative to the normalised pool of all samples (error bars represent 95%CI).

The New CN ThunderCats

Changes in the average abundance of histidine and histidine-derived muscle-associated amino acid derivatives. Both histidine and carnosine decrease significantly in CN compared to EN cats during sexual development and increase to levels similar to EN cats within 2 weeks of neutering (CN (red) and EN (black)). Anserine, the final product detected in this pathway increases significantly in CN cats during sexual development and remains at a stable level, whilst EN cats show a steady increase throughout development. Scaled intensity is relative to the normalised pool of all samples (error bars represent 95% CI).

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Home · Purina · Purina Veterinary Diets For Cats; Purina Canine & Feline CN Critical .. Changes in the average abundance of sterol- and tryptophan-associated metabolites with significant increases in CN compared to EN cats during sexual development ((CN (red) and EN (black)). Scaled intensity is relative to the normalised pool of all samples (error bars represent 95% CI).

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Changes in the average abundance of sterol- and tryptophan-associated metabolites with significant increases in CN compared to EN cats during sexual development ((CN (red) and EN (black)). Scaled intensity is relative to the normalised pool of all samples (error bars represent 95% CI).

Cartoon Network 20th Anniversary: Bumper - "Cats"


“The People,” as the CN cats call them, are the — aka Dunn, her husband Ryan Faillace, and their 3-year-old son Luke and 1-year-old daughter Guinevere, who all live in the Seattle area.Neutering is a significant risk factor for obesity in cats. The mechanisms that promote neuter-associated weight gain are not well understood but following neutering, acute changes in energy expenditure and energy consumption have been observed. Metabolic profiling (GC-MS and UHPLC-MS-MS) was used in a longitudinal study to identify changes associated with age, sexual development and neutering in male cats fed a nutritionally-complete dry diet to maintain an ideal body condition score. At eight time points, between 19 and 52 weeks of age, fasted blood samples were taken from kittens neutered at either 19 weeks of age (Early Neuter (EN), n = 8) or at 31 weeks of age (Conventional Neuter (CN), n = 7). Univariate and multivariate analyses were used to compare plasma metabolites (n = 370) from EN and CN cats. Age was the primary driver of variance in the plasma metabolome, including a developmental change independent of neuter group between 19 and 21 weeks in lysolipids and fatty acid amides. Changes associated with sexual development and its subsequent loss were also observed, with differences at some time points observed between EN and CN cats for 45 metabolites (FDR pThe Cat Network, Inc. (CN) is a 501(c)3, Florida not-for-profit corporation dedicated to humanely reducing cat overpopulation by educating the public about the need to sterilize their pets and strays; providing access to low-cost spay/neuter services for stray, homeless and abandoned cats; helping members in their efforts to place adoptable cats in loving homes; and advocating non-lethal population control and humane public policy. Neutering, at any age, is reported to be associated with an increased risk of weight gain. To determine if neutering had a similar effect on metabolism irrespective of age, the metabolic profiles were analysed between the samples from the final pre-neuter time point and the first post-neuter time point two weeks later. Only retinoate and trans-4-hydroxyproline changed in both EN and CN cats (1.47- and 1.7- fold increase and 0.77- and 0.67-fold change respectively), indicating that any acute neuter-related changes were mostly resolved by two weeks post-procedure or were dominated by factors related to the different metabolic status of the groups prior to neutering.