Other drugs to help stimulate a cat’s appetite include anabolic steroids, such as nandrolone decanoate and stanozolol. Unfortunately, adverse effects are common, and can be quite serious. For this reason, they are no longer recommended for appetite stimulation.
In conclusion, mirtazapine works as an appetite stimulant in cats.
is an antidepressant used to treat moderate to severe depression in people. is not a serotonin or reuptake inhibitor (SSRIs such as are noted to decrease appetite). It is an antagonist of presynaptic α2-adrenergic autoreceptors and heteroreceptors on both and serotonin (5-HT) presynaptic axons, plus is a potent antagonist of postsynaptic 5-HT2 and 5-HT3 receptors. This mechanism of action maintains equivalent antidepressant efficacy but minimizes many of the adverse effects common to both tricyclic antidepressants and SSRIs. Because of its unique pharmacologic profile, usually does not cause anticholinergic effects, serotonin-related adverse effects, or adrenergic adverse effects (orthostatic hypotension and sexual dysfunction). Antihistaminic drowsiness is a common effect. is used for disease conditions in which inappetance and nausea go together, such as in the treatment of GI disease or liver or kidney disease. can also be used to alleviate the nausea and appetite loss that accompanies chemotherapy. α-Adrenergic receptors in the chemoreceptor trigger zone are important in inducing emesis in cats. Clinically, is an effective appetite stimulant and antiemetic for cats with chronic kidney disease and appears to be a useful adjunct in nutritional management of these cats. There is little pharmacokinetic information on in dogs and cats, but shows sexual effects in hepatic metabolism in people, so it is likely there is similar variation in metabolism in dogs and cats and the potential for variation in efficacy.
Appetite Stimulants for Cats – When Cat Will Not Eat | petMD
acetate is a synthetic progestin. It has significant antiestrogen and glucocorticoid activity, with resulting adrenal suppression. It is used to stimulate appetite and promote weight gain in people with cancer and cachexia (related to acquired immunodeficiency syndrome) and may have a similar effect in anorectic cats and dogs. acetate is contraindicated in pregnant animals and in animals with uterine disease, diabetes mellitus, or mammary neoplasia. In cats, acetate can induce a profound adrenocortical suppression, adrenal atrophy, and diabetes mellitus, which may or may not be reversible. Toxicity is less of a problem in dogs.
Appetite Stimulants for Cats - Tufts Catnip Article