Fipronil is the active ingredient in Frontline Plus for cats; imidacloprid and pyriproxyfen are the active ingredients in Advantage II. Unlike many other insecticides, fipronil works by attacking the nerves in the fleas' spinal cords and brains. The fleas die as a result of uncontrolled activity. Imidacloprid works by attacking the central nervous system of those pesky fleas. Imidacloprid attacks certain receptors in the fleas. The neuron then is unable to make any signals, eventually resulting in death. Pyriproxyfen is an insect growth regulator that kills fleas in all stages of life. Advantage Multi, another Advantage product from Bayer, also contains the active ingredient moxidectin. Moxidectin in Advantage Multi attacks the nervous system of heartworms and intestinal parasites, making Advantage Multi an ideal product to protect your kitty from various parasites. (SEE REFS 2, 3, 5)
Frontline vs Advantage for Cats | PetCareRx
Hi Natasha: Thanks for your article: I have used Revolution and it works great, just really expensive. I have 2 cats that are indoor cats. Never had a problem until recently because I have moved in with my sister who has 2 dogs. She keeps them protected but they are carrying the fleas inside….so my cats now have them and they are also using me for dinner as well. I heard that Frontline Plus works but you have to reapply every 21 days instead of 30 like they say. Do you think I should get tick control as well, or just flea control. I have never used Advantage. I just know I need to get something quick. How long does it take to get rid of them completely?
Waterproof against Adult fleas, flea larvae, and eggs
I love DMOPC and happy with everything else I've purchased but this didn't work for my cat. I had already tried Frontline Plus without results. For several reasons, I assumed my FP was a bad batch so I bought the Martin's (has the same active ingredients). The Martin's had no effect on my cat's fleas either. I tried the Advantage II and it worked perfectly. I know this works for most people and don't know why it hasn't worked for me - whether it's the Texas weather or the Texas fleas.
Compare Advantage II to Frontline Plus - 1800PetMeds