Advantage II for Cats is a once-a-month topical flea prevention for cats and kittens over 8 weeks old. Contains Imidacloprid, an adulticide, and Pyriproxyfen, an insect growth regulator. Advantage II for Cats controls existing flea infestations on your cat and prevents further infestations. Kills all flea life stages. Kills fleas within 12 hours of application. Prevents further infestations for up to 4 weeks. Waterproof.
Advantage Flea Control for Cats and Kittens Over 9 lbs 4 Month Supply
So which, of all the products available, do I recommend for my feline patients? Certainly not Advantage II. Comfortis appears to be the most effective and I recommend it for cats with major flea allergies. But for most cats, a generic product containing fipronil is sufficient.
Advantage Flea Control for Cats and Kittens Over 9 lbs ..
The speed of flea kill does tend to wane during the month following dosing with Advantage flea control (as it does for all three major topical preparations prescribed by vets). A 2005 study published in Veterinary Therapeutics demonstrated this. It showed that Imidacloprid (Advantage flea control) had the highest % flea kill within 6 hours of initial dosing (out of Fipronil, Imidacloprid and Selamectin), but that all products had achieved a >95% flea kill by 24 hours of dosing. Fleas were re-introduced to the cats at day 7 (to mimic a reinfestation event) and all three formulations showed a similar effect, with a 68.4% flea kill at 6 hours post flea-introduction and a massive (highly effective) 99.4% flea eradication at 24 hours. At day 21 and then again at day 28, more fleas were introduced and there was no appreciable kill of those fleas within 6 hours. The new fleas did die, but they took longer (up to 2 days were allowed before the % flea kill was determined), showing that the speed of kill declines with the time passed since dosing.
Advantage Flea Control for Cats - My Healthy Cat